The neurobiology of cocaine cellular and molecular mechanisms

Cover of: The neurobiology of cocaine |

Published by CRC Press in Boca Raton .

Written in English

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Subjects:

  • Cocaine -- Physiological effect.,
  • Neuropharmacology.,
  • Cocaine -- pharmacology.,
  • Neurotansmitters -- metabolism.,
  • Central Nervous System -- drug effects.

Edition Notes

Includes bibliographical references and index.

Book details

Statementedited by Ronald P. Hammer, Jr.
ContributionsHammer, Ronald P.
Classifications
LC ClassificationsQP801.C68 N48 1995
The Physical Object
Pagination255 p. :
Number of Pages255
ID Numbers
Open LibraryOL1275444M
ISBN 100849383110
LC Control Number95007021

Download The neurobiology of cocaine

Book Description Representing the latest data from active research groups, The Neurobiology of Cocaine is designed to educate students and inform experts in a rapidly changing field.

This volume presents current research regarding the mechanisms of cocaine's action in the brain. Key Features Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Illustrated in full color Provides unique full coverage of all aspects of cocaine and its related pathology Provides researchers with an up-to-date understanding of the.

By reading The Neurobiology of Cocaine Addiction, you will sharpen your knowledge of the basic actions of cocaine, the factors related to daily cocaine use, the neurobiological basis of addictive diseases, and drug-induced alterations in normal physiology.

You will also learn about: the coexistence of cocaine and heroin addictionBrand: Taylor And Francis. Summary Cocaine has potent pharmacological actions on a number of monoaminergic systems in the brain, including those that use noradrenaline, dopamine and serotonin as by: The Neuroscience of Cocaine: Mechanisms and Treatment explores the complex effects of this drug, addressing the The neurobiology of cocaine book behind cocaine use and the psychosocial and behavioral factors that impact cocaine use and abuse.

This book provides researchers with an up-to-date understanding of the mechanisms behind cocaine use, and aids them in deriving new pharmacological compounds and. Description: The Neuroscience of Cocaine: Mechanisms and Treatment explores the complex effects of this drug, addressing the neurobiology behind cocaine use and the psychosocial and behavioral factors that impact cocaine use and abuse.

This book provides researchers with an up-to-date understanding of the mechanisms behind cocaine use, The neurobiology of cocaine book aids them in deriving new. Cocaine dependence is a devastating disorder that is associated with a host of medical and psychosocial risks.

This complex disorder is made up of distinct clinical components that are interwoven into a cycle of addiction ().Cocaine activates ancient pleasure centers that dominate our thoughts, behaviors, and priorities, producing a pleasure-reinforced compulsion to use the : Charles A.

Dackis. By reading The Neurobiology of Cocaine Addiction, you will sharpen your knowledge of the basic actions of cocaine, the factors related to daily cocaine use, the neurobiological basis of addictive diseases, and drug-induced alterations in normal physiology. You will also learn about: the coexistence of.

The neurobiology of cocaine addiction. Nestler EJ(1). Author information: (1)Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TXUSA.

[email protected] Comment in Sci Pract Perspect. Dec;3(1)Cited by: The abuse and addiction potential of cocaine results, at least partly, from its effects on specific neurotransmitter systems of the brain. Recent laboratory research has established that cocaine and other drugs of abuse act directly on the brain’s reward by: The Neurobiology of Cocaine: Cellular and Molecular Mechanisms - CRC Press Book Representing the latest data from active research groups, The Neurobiology of Cocaine is designed to educate students and inform experts in a rapidly changing field.

The Cocaine and Dopamine video tutorial covers the essential neurobiology background needed to complete the lab. It is a condensed version of the three books found in the desk area. This tutorial can be used instead of, or in addition to the reading associated with the lab. The Neuroscience of Cocaine: Mechanisms and Treatment explores the complex effects of this drug, addressing the neurobiology behind cocaine use and the psychosocial and behavioral factors that impact cocaine use and abuse.

This book provides researchers with an up-to-date understanding of the mechanisms behind cocaine use, and aids them in.

The focus of the book is on the brain processes underlying addiction, in terms of neural systems, neurochemical basis, and molecular changes. Several types of addiction are discussed ranging from illicit drugs - cocaine, amphetamine, and heroin to legal drugs - alcohol and nicotine.5/5(2).

Neurobiology of Cocaine Addiction by Herman Joseph, Regina Quattrochi starting at $ Neurobiology of Cocaine Addiction has 2 available editions to buy at Half Price Books Marketplace. Cocaine dependence is a devastating disorder that is associated with a host of medical and psychosocial risks.

This complex disorder is made up of distinct clinical components that are interwoven into a cycle of addiction (Figure 1). Cocaine activates ancient pleasure centers that dominate our thoughts, behaviors, and priorities, producing a pleasure-reinforced compulsion toAuthor: Charles A.

Dackis. The Neurobiology of Cocaine Addiction: From Bench to Bedside (Journal of Addictive Diseases) eBook: Herman Joseph, Regina Quattrochi: : Kindle Store. The Neurobiology of Cocaine Addiction: From Bench to Bedside by Herman Joseph and Regina Quattrochi (, Paperback).

Genre/Form: Congress: Additional Physical Format: Online version: Neurobiology of cocaine addiction. New York: Haworth Medical Press, © (OCoLC)   Cocaine in the s. The History of Cocaine. The Neurobiology of Cocaine. The Clinical Manifestations of Cocaine Abuse.

Outpatient Treatment. Inpatient Treatment and Relapse Prevention. Pharmacological Treatments. The Role of Drug Testing. Eating Disorders and Substance Abuse. Physicians, the Elderly, Adolescents, and Substance Abuse. : Mark S. Gold. with the type of drug used.

For example, with stimulants such as cocaine, the “high” is followed by feelings of power, self-confidence, and increased energy.

In contrast, the euphoria caused by opiates such as heroin is followed by feelings of relaxation and satisfaction.

z To feel better. The consummatory component represents the actual “consuming” of the goal (e.g., cocaine reaches the brain). An important question in the neurobiology of cocaine concerns the role of dopamine: If cocaine increases brain dopamine when consumed, does dopamine only play a role during the consummatory phase of cocaine use.

Cocaine and the Brain: The Neurobiology of Addiction In the eyes of the public, the word addict stirs up a negative image: a person of low moral character who willfully chooses to engage in questionable behavior. This image is perpetuated in the media; on a recent episode of E.R., the chief surgeon.

Neurobiology. In general, cocaine acts by blocking the reuptake of neurotransmitters, such as norepinephrine, dopamine, and serotonin, at the synaptic junction. As a result, there is an accumulation of neurotransmitters causing continuous stimulation that leads to the pleasurable effects reported by cocaine users.[] These effects include.

The Neuroscience of Cocaine | The Neuroscience of Cocaine: Mechanisms and Treatment explores the complex effects of this drug, addressing the neurobiology behind cocaine use and the psychosocial and behavioral factors that impact cocaine use and abuse.

A study in rats has found that stimulating a key part of the brain reduces compulsive cocaine-seeking and suggests the possibility of changing addictive behavior generally. The study, published in Nature, was conducted by scientists at the Intramural Research Program of the National Institute on Drug Abuse (NIDA), part of the National.

Cocaine Interactions with the Endogenous Opioid System / Ellen M. Unterwald --Ch. Neurochemistry of Cocaine Withdrawal / Friedbert Weiss, Loren H.

Parsons and Athina Markou --Ch. Chronic Cocaine Action on the Dopamine Transporter / Nancy R. Zahniser, Greg A. Gerhardt and Wayne A. Cass. Request PDF | The Neurobiology of Cocaine Addiction | Cocaine produces its psychoactive and addictive effects primarily by acting on the brain's limbic system, a set of interconnected regions that.

The focus of the book is on the brain processes underlying addiction, in terms of neural systems, neurochemical basis, and molecular changes.

Several types of addiction are discussed ranging from illicit drugs - cocaine, amphetamine, and heroin to legal drugs - alcohol and nicotine.5/5(1). The role of dopamine in addiction. Addictive drugs are inherently rewarding. They highjack the brain's dopamine system to increase dopamine levels in the nucleus accumbens, a key focal point for reward neurocircuitry in the brain.6 While dopamine is critical for the rewarding effects of drugs, its role in substance use disorders is still evolving.

Nearly 20 years ago, Nora Volkow (National Cited by: Much effort has been focused on the development of pharmacotherapies for cocaine use disorder, yet there are no FDA-approved medications.

Cocaine exerts its powerful reinforcing effects by acting on mesocorticolimibic circuitry that is primarily associated with dopamine neurotransmission.

Accumulating evidence continues to implicate the noradrenergic system as key to cocaine’s effects. Neurobiology of Brain Disorders is the first book directed primarily at basic scientists to offer a comprehensive overview of neurological and neuropsychiatric disease.

This book links basic, translational, and clinical research, covering the genetic, developmental, molecular, and cellular mechanisms underlying all major categories of brain. The premier text on substance abuse and addictive behaviors is now in its updated and expanded Fourth Edition, with up-to-the-minute insights from more than experts at the front lines of patient management and research.

This edition features expanded coverage of the neurobiology of abused substances, new pharmacologic therapies for addictions, and complete information on “club drugs 4/5(3). Cocaine binds to the serotonin (5-hydroxytryptamine; 5-HT) transporter, inhibits reuptake, and increases extracellular 5-HT efflux within limbic-corticostriatal circuitry involved in CUD neurobiology.

The role of 5-HT in the in vivo effects of cocaine depends upon the 5. The neurobiology of cocaine addiction: from bench to bedside. Add to My Bookmarks Export citation. Type Book Author(s) Joseph, Herman, Stimmel, Barry Date c Publisher Haworth Medical Press Pub place New York Volume Journal of addictive diseases series ISBN  Animals models have begun to provide insights into the neurobiological basis of reinforcement in drug addiction.

The reinforcing effects of indirect sympathomimetics such as cocaine and amphetamine appear to depend on release of dopamine in the terminal fields of the mesocorticolimbic dopamine system.

Cycles of methamphetamine and cocaine abuse have occurred throughout the world for more than a century. Although abuse of both drugs has declined in the United States in the past 10 years, records of emergency room visits, drug treatments, and arrests demonstrate.

The Neurobiology of Liking, Wanting, and the True Will. June 5, sex, money, cocaine, etc.) cues = perceptual or cognitive reminders of a reward, which may be innate incentive stimuli (e.g., the smell of a pizza), conditioned stimuli (e.g., a notification on the phone), imagined stimuli (e.g., thinking about a sexually attractive person), or.

The first book of Samuel mentions Saul's uncontrolled violent behavior several times. In Chap it is written "And Will work for morphine or cocaine 15 Neurobiology of addiction.

Disease model ; AA is founded by a physician and business man. By behavioral sensitization, repeated exposure to a rewarding or stressful stimulus can lead to enhanced responses to the stimulus over a prolonged period. It appears related to development of addictive behavior and to relationships between addictions and other disorders.

This chapter focuses on sensitization to stimulants, especially cocaine, because of its direct relevance to addictive. OBJECTIVE: A primary behavioral pathology in drug addiction is the overpowering motivational strength and decreased ability to control the desire to obtain this review the authors explore how advances in neurobiology are approaching an understanding of the cellular and circuitry underpinnings of addiction, and they describe the novel pharmacotherapeutic targets emerging from this.

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